Role and Indications for Device Therapies in Heart Failure: Condensed Summary

Authors

  • Eileen O’Meara, MD Montreal Heart Institute, Montreal QC.Universite de Montreal, Montreal, QC
  • Blandine Mondésert, MD, FCHRS Montreal Heart Institute, Montreal, QC

DOI:

https://doi.org/10.58931/cct.2025.127

Abstract

Over the past decade, the substantial benefits associated with current guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF) have been brought into the light, as emphasized in a recent publication from our institution. Despite these advances, device therapy continues to hold an important place in treating heart failure (HF), both for left ventricular (LV) remodeling (and associated prognosis) as well as for preventing sudden cardiac death (SCD).

Cardiac resynchronization therapy (CRT) is a key intervention in heart failure (HF) management, particularly for patients with left bundle branch block (LBBB), which is observed in 15–25% of patients with HF, and is associated with reduced left ventricular function. CRT helps in correcting dyssynchronous ventricular contraction leading to impaired cardiac output. Although less prevalent, right bundle branch block (RBBB) and nonspecific interventricular conduction delay (IVCD) are also associated with adverse remodelling, including increased right ventricular volumes and reduced function.

Author Biographies

Eileen O’Meara, MD, Montreal Heart Institute, Montreal QC.Universite de Montreal, Montreal, QC

Dr. Eileen O’Meara is a professor at Université de Montréal and at the MontrealHeart Institute. She completed a Fellowship in Heart Failure, and another in Stress Echocardiography. She holds the MHI Carolyn and Richard J Renaud’s research chair in Heart Failure and is the co-director of the Myocardial Research Axis at MHI. She is a member of the Internal Review Board, of the Research Core Echocardiography Laboratory and of the Pharmacology Committee at MHI, as well as Chief of Outpatients Clinics at MHI. She was Co-Chair of the Primary Panel for the Canadian Cardiovascular Society and Canadian Heart Failure Society (CCS and CHFS) HF Guidelines and co- chair of the Cardiorenal Protection Guidelines for the CCS/CHFS (2020-2022). She is a section lead for the soon to be published CCS HFpEF guidelines. Her research focuses on cardio-kidney-inflammation interactions and fibrosis in HF, including circulating and cardiac imaging biomarkers; as well as on comorbid conditions that contribute to HF, more specifically diabetes/adiposity, CKD, anemia and arrhythmia. She is involved in several large HF clinical trials as a National Lead Investigator, SC or EC member.

Blandine Mondésert, MD, FCHRS, Montreal Heart Institute, Montreal, QC

A French cardiologist who graduated from the University of Grenoble in 2008, Dr. Blandine Mondésert worked for two years as a senior arrhythmia clinician at the Grenoble University Hospital in France. She was also recognized as a cardiologist by the Collège des Médecins du Québec, through the France-Quebec agreements in July 2013. She subsequently completed a fellowship in electrophysiology at the Montreal Heart Institute between 2011 and 2013, where she specialized in the fields of electrophysiology (pacing and ablation), particularly in adult patients with congenital heart disease, within Dr. Paul Khairy’s team. She also developed expertise in the extraction of implantable cardiac equipment, for which she completed her extraction training at the Lille University Hospital in France in 2014. In July 2014, Dr. Blandine Mondésert joined the team at the Montreal Heart Institute, where she works as a cardiologist. She also serves as an assistant clinical professor of medicine at the University of Montreal.

References

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Published

2025-09-29

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1.
O’Meara E, Mondésert B. Role and Indications for Device Therapies in Heart Failure: Condensed Summary. Can Cardiol Today [Internet]. 2025 Sep. 29 [cited 2025 Oct. 26];1(2):15–21. Available from: https://canadiancardiologytoday.com/article/view/1-2-OMeara_et_al

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Volume 1, Issue 2, Summer 2025

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